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U principu, lečenje ne bi smelo da traje duže od 8-twelve nedelja, uključujući i period of time postepene obustave leka. Terapija se ne sme produžavati bez prethodne reevaluacije stanja pacijenta.Benzodiazepini nisu indikovani kod pacijenata sa teškim oštećenjem funkcije jetre, s obzirom na to da mogu da izazovu nastanak encefalopatije. Kod

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